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What is Hantavirus?

Disease overview — WHO, CDC & ECDC guidance

Last updated: 2026-05-07

Hantaviruses are a family of rodent-borne viruses. Human infection is uncommon but can be severe, with two distinct disease patterns depending on the viral strain and the region of the world.

HPS

Hantavirus Pulmonary Syndrome

Found across the Americas. Primarily affects the lungs. Case-fatality reported up to ~38% (CDC).

Main virus Sin Nombre (North America), Andes (South America)
P2P spread Andes virus only
HFRS

Hemorrhagic Fever with Renal Syndrome

Reported across Europe and Asia. Primarily affects kidneys, with bleeding and shock in severe cases. Case-fatality 1–15% depending on strain.

Main virus Hantaan, Seoul (Asia) · Puumala, Dobrava (Europe)
P2P spread Not documented

How does hantavirus spread?

Hantaviruses circulate in wild rodents, which shed the virus in urine, droppings and saliva without showing illness themselves. Humans are infected almost exclusively through environmental contact, not from other people.

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Inhalation Primary route

Breathing aerosolised dust contaminated with rodent excreta — often when cleaning closed sheds, cabins or barns.

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Direct contact

Touching rodents or contaminated surfaces, then touching eyes, nose or mouth.

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Rodent bites

Rare route of transmission.

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Person-to-person

Generally not documented. The Andes virus in southern Argentina and Chile is the established exception with limited human-to-human spread.

Who is at risk?

Risk is driven by exposure to rodent habitats, not by age or general health.

🏚️Rural residents with rodent activity nearby
Hikers and campers in endemic regions, especially cabins
🧹Workers cleaning long-closed buildings, sheds, attics or barns
🌾Agricultural, forestry and grain-handling workers
🔬Researchers and pest-control workers in contact with wild rodents

Prevention

⚕️ No specific antiviral exists. Prevention is environmental and behavioural.
1Seal entry points larger than 6 mm in homes, sheds and outbuildings.
2Store food and pet food in rodent-proof containers; remove nesting material.
3Before cleaning a closed space, ventilate it for at least 30 minutes.
4Wet droppings and nests with a disinfectant or 1:10 bleach solution before removing — never sweep or vacuum dry material.
5Use disposable gloves and a well-fitting FFP2/N95 mask for cleanup.

Diagnosis & Treatment

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Diagnosis

Confirmed through serology (IgM/IgG antibodies) or PCR. Early symptoms resemble influenza — always mention rodent exposure to a clinician.

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Treatment

Supportive care only: oxygen and intensive care for HPS; fluid and kidney management for HFRS. Early hospital care significantly improves outcomes.

Vaccine status

No vaccine approved in the USA or EU.
Inactivated HFRS vaccines used in China and South Korea against Hantaan and Seoul viruses.
🔬Several candidate vaccines in research; none widely available.

Frequently asked questions

How long after exposure do symptoms appear?

The incubation period is typically 1 to 8 weeks. Most people develop symptoms within 2 to 4 weeks.

Is hantavirus contagious between people?

Person-to-person transmission is generally not documented. The one well-described exception is the Andes virus in southern Argentina and Chile, which has shown limited human-to-human spread.

What should I do if I think I've been exposed to rodent droppings?

Avoid sweeping or vacuuming dry droppings. Ventilate the area, wet contaminated surfaces with disinfectant or bleach, wear gloves and a well-fitting mask, and watch for fever, muscle aches or shortness of breath in the following 1 to 8 weeks. Seek medical care early if symptoms appear.

Where is hantavirus most common?

HPS occurs across the Americas, with hotspots in the U.S. Four Corners region and Patagonia. HFRS is most reported in China, the Korean peninsula, Russia, the Balkans, Scandinavia and parts of central Europe.